Professor Stefan E.H. Alexson:
|Professor Stefan E.H. Alexson
Professor Stefan Alexson, Karolinska Institutet is particularly focusing on enzymes that regulate cellular levels of acyl-CoA/free fatty acids, which have impact on the metabolism of these lipids. The main interest is to study the importance of an increasing number of acyl-CoA thioesterases with different cellular locations (mitochondria, peroxisomes and cytosol) and substrate specificities in regulation of fatty acid metabolism. Also the role of various nuclear receptors that regulate different pathways of lipid synthesis and degradation is becoming increasingly evident. Several acyl-CoA thioesterases are target genes for nuclear receptors, and they are currently studying the roles of various nuclear receptors and acyl-CoA thioesterases in the intestine. The main focus within this program is to study factors that regulate uptake of lipids across the intestine, which may be considered a gate-keeper for over-all lipid homeostasis, and signaling between the intestine and the liver as well as other organs. They have also recently identified novel enzymes that are involved in conjugation of fatty acids to the amino acids taurine and glycine, which suggest the existence of a new and intriguing pathway for lipid metabolism/excretion.